Anistreplase is known as a prodrug of streptokinase that has which of the following features?

Anistreplase, as a prodrug of streptokinase, is characterized by its increased specificity for clot-bound fibrin, which is a significant advantage in thrombolytic therapy. This feature means that it preferentially targets and binds to fibrin that is already part of a thrombus (blood clot), leading to more effective lysis of the clot while minimizing the impact on circulating fibrinogen or non-clot-bound fibrin. The specificity enhances its efficacy in clearing occlusive clots in conditions such as myocardial infarction or stroke, as it facilitates more selective clot dissolution.

The other features do not accurately describe Anistreplase. For instance, it does not have a shorter half-life compared to streptokinase; instead, its pharmacokinetics can vary based on the formulation. Additionally, while it possesses some level of lysis activity, it is not inherently non-specific as its design aims for greater specificity in action. Lastly, while it is believed to have a reduced risk of allergic reactions compared to streptokinase, the emphasis on clot-bound fibrin is a hallmark feature essential for its therapeutic use. Therefore, the correct answer highlights its enhanced specificity, which is key to its mechanism of action and clinical effectiveness.