Clopidogrel primarily works by forming a bond with which amino acid on the platelet?

Clopidogrel primarily exerts its effects by forming a covalent bond with cysteine residues on the P2Y12 receptor located on platelets. This interaction is crucial because it leads to the inhibition of adenosine diphosphate (ADP) binding to this receptor. By inactivating the P2Y12 receptor, clopidogrel effectively prevents platelet activation and aggregation, which is essential for preventing thrombus formation. This mechanism of action underlines the importance of cysteine in the binding process, as it allows clopidogrel to impart its antiplatelet effects and enhance cardiovascular protection.