For what specific condition is Aspirin particularly well-supported?

Aspirin is particularly well-supported for the primary prevention of cardiovascular disease in high-risk individuals because it has been shown to reduce the risk of heart attacks and strokes in these patients. The rationale behind its use lies in Aspirin's ability to inhibit platelet aggregation, which is a key factor in the formation of blood clots that can lead to cardiovascular events. Clinical trials and guidelines suggest that in individuals who have a high risk of developing cardiovascular disease, such as those with certain risk factors like hypertension, diabetes, or elevated cholesterol levels, using Aspirin can provide significant protective benefits.

While Aspirin is also beneficial in secondary prevention for those who have already experienced cardiovascular events or are diagnosed with atherosclerotic disease, its role in primary prevention is especially well-supported when considering the specific group of high-risk individuals. This means that for patients who have not yet experienced a heart attack or stroke but are at a higher risk of such events, Aspirin can be an effective preventive strategy.