In which patients is Prasugrel contraindicated?

Prasugrel is contraindicated in patients over 75 years of age primarily due to the increased risk of bleeding complications associated with older adults. In this age group, the pharmacodynamics and pharmacokinetics of medications can differ significantly, often leading to more pronounced effects. Specifically, the risk of serious or fatal bleeding tends to increase with advancing age. Clinical studies and guidelines suggest careful consideration or avoidance of Prasugrel in elderly patients, particularly those who might have a higher baseline bleeding risk or who are not undergoing a percutaneous coronary intervention (PCI).

In pregnant women, those with a history of liver disease, or patients with asthma, the caution would be based on individual assessments, but the age factor specifically complicates the use of Prasugrel due to the inherent risks associated with age-related physiology.