Which enzyme metabolizes vorapaxar?

Vorapaxar is metabolized primarily by the enzyme CYP3A4, which is a key player in the cytochrome P450 family involved in drug metabolism. This enzyme facilitates the oxidation process, leading to the conversion of vorapaxar into its active and inactive metabolites. The metabolism of vorapaxar through CYP3A4 is significant because it influences the drug's pharmacokinetics, including its efficacy and safety profile. As a result, the activity of CYP3A4 can affect how well vorapaxar works in patients and can interact with other medications that inhibit or induce this enzyme, potentially altering the plasma levels and therapeutic effects of vorapaxar. Understanding the role of CYP3A4 in vorapaxar metabolism is crucial for optimizing antiplatelet therapy and managing potential drug interactions.