Which factor is NOT affected by tenecteplase?

Tenecteplase is a recombinant tissue plasminogen activator that is primarily used to promote the dissolution of blood clots by converting plasminogen to plasmin. This action leads to the breakdown of fibrin, which is essential in clot formation. In this process, various factors are influenced.

Fibrinogen, which is converted into fibrin during the coagulation cascade, is affected by tenecteplase as it operates on the fibrinolytic system. Similarly, plasminogen is directly targeted by tenecteplase; it is the substance that is converted into plasmin, thereby initiating the clot breakdown process. The activation of thrombin is part of the coagulation cascade leading to fibrin formation, which can subsequently be influenced by the effects of thrombolysis as activated plasmin breaks down fibrin.

On the other hand, vitamin K plays a crucial role in the synthesis of certain clotting factors, but it is not influenced by tenecteplase’s mechanism of action. Vitamin K is essential for the synthesis of factors II (prothrombin), VII, IX, and X, which are necessary for blood coagulation, but tenecteplase does not affect vitamin K levels or its action