Which is the primary mechanism of action for streptokinase?

Streptokinase primarily works through the mechanism of direct fibrinolysis. It is an enzyme that converts plasminogen, a inactive precursor, into plasmin, which is the active enzyme responsible for breaking down fibrin and dissolving blood clots. By promoting the conversion of plasminogen to plasmin, streptokinase effectively enhances the body’s ability to dissolve clots that have already formed in blood vessels, thereby restoring blood flow in cases such as myocardial infarction or pulmonary embolism.

Understanding the role of streptokinase in fibrinolysis highlights its importance as a thrombolytic agent. Unlike agents that might activate platelets or inhibit thrombin, streptokinase targets existing clots, directly aiding in their breakdown rather than preventing their formation or influencing platelet activity. This makes it particularly useful in acute settings where rapid restoration of circulation is vital for patient outcomes.