Which metabolite of Clopidogrel is considered inactive?

The metabolite of Clopidogrel that is considered inactive is indeed the COOH Metabolite. Clopidogrel is a prodrug that requires metabolic activation to exert its antiplatelet effect, primarily through the formation of an active thiol metabolite. After it undergoes biotransformation, the active metabolite irreversibly binds to the P2Y12 receptor on platelets, inhibiting their aggregation.

The COOH Metabolite forms as a product of Clopidogrel's metabolism, but it lacks the necessary pharmacological activity to influence platelet function. Its role in the body is more about further processing of the drug rather than contributing to the therapeutic effect.

In contrast, other metabolites mentioned may involve active or unstable forms that have roles in platelet inhibition or vary in their efficacy. Understanding these different pathways and metabolite activities is crucial for appreciating how antiplatelet agents like Clopidogrel function in clinical settings.