Which organ clears urokinase from the body?

Urokinase is primarily cleared from the body by the kidneys. This serine protease plays a significant role in the conversion of plasminogen to plasmin, which helps in the breakdown of blood clots. Although the liver is involved in the metabolism and clearance of various substances, urokinase is predominantly eliminated through renal processes. The kidneys filter blood and remove waste products, including drugs and enzymes like urokinase, which get excreted in the urine. Understanding the organ-specific clearance mechanisms can help in managing dosages and potential effects of drugs that act on hemostasis, including urokinase, especially in clinical settings related to thrombolysis and cardiovascular health.