Which two adverse effects are associated with the use of streptokinase?

Streptokinase is a thrombolytic agent used primarily in the treatment of acute myocardial infarction and other clot-related conditions. One of the well-documented adverse effects associated with its use is a bleeding disorder, which can occur due to its mechanism of action that promotes the breakdown of fibrin clots, potentially leading to excessive bleeding.

Additionally, hypersensitivity reactions are another notable adverse effect. Since streptokinase is derived from streptococcal bacteria, some patients may have pre-existing antibodies against it, leading to allergic reactions. These hypersensitivity reactions can manifest as rash, fever, or even more severe anaphylactic responses.

In contrast, nausea and vomiting, headaches and dizziness, and fatigue and dehydration, while they may occur with various medications, are not the primary concerns specifically associated with streptokinase use. The most significant risks are indeed related to bleeding trouble and potential allergic reactions, making the identification of those adverse effects crucial for healthcare providers when administering this thrombolytic agent.